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Targeted Allele Detail
Symbol: Rpgrtm1Tili
Name: retinitis pigmentosa GTPase regulator; targeted mutation 1, Tiansen Li
MGI ID: MGI:2386674
Synonyms: RPGR-
Gene: Rpgr  Location: ChrX:10073621-10216920 bp, - strand  Genetic Position: ChrX, 4.62 cM
Light micrographs of retinal sections of wild-type and Rpgrtm1Tili/Rpgrtm1Tili mice.

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:61371
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPart of exon 4 through part of exon 6 was replaced with a promoter-less lacZ-neo cassette via homologous recombination. Northern blot analysis using a full length cDNA probe did not detect gene expression in brains from homozygous mutant animals. RT-PCR analysis also did not detect gene transcripts. Western blot analysis of protein from brain, retina, and testis confirmed the null allele. (J:61371)
View phenotypes for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rpgr Mutation:  1 strain or line available
Original:  J:61371 Hong DH, et al., A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for X-linked retinitis pigmentosa (RP3). Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3649-54
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory