About   Help   FAQ
Fmn1tm2Led
Targeted Allele Detail
Nomenclature
Symbol: Fmn1tm2Led
Name: formin 1; targeted mutation 2, Philip Leder
MGI ID: MGI:2386599
Synonyms: fmn5KO
Gene: Fmn1  Location: Chr2:113327771-113709855 bp, + strand  Genetic Position: Chr2, 57.3 cM, cytoband C1-qter
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50647
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 5 was replaced by a PGK-neo cassette inserted by homologous recombination. Circular transcripts were undetected by RT-PCR analysis of brain and kidney samples obtained from homozygous mutant mice. Ribonuclease protection assays showed that transcripts lacking the targeted exon were present at normal levels in homozygous mutant mice. Corresponding results were obtained by Western blot analysis. (J:50647)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fmn1 Mutation:  33 strains or lines available
Notes
Homozygous mutant mice have normal limbs, but display variably penetrant renal aplasia characteristic of other limb deformity mutant alleles (J:50647).
References
Original:  J:50647 Chao CW, et al., The mouse formin (Fmn) gene: abundant circular RNA transcripts and gene-targeted deletion analysis. Mol Med. 1998 Sep;4(9):614-28
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/27/2016
MGI 6.05
The Jackson Laboratory