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Targeted Allele Detail
Symbol: Fmn1tm2Led
Name: formin 1; targeted mutation 2, Philip Leder
MGI ID: MGI:2386599
Synonyms: fmn5KO
Gene: Fmn1  Location: Chr2:113327771-113709855 bp, + strand  Genetic Position: Chr2, 57.3 cM, cytoband C1-qter
Germline Transmission:  Earliest citation of germline transmission: J:50647
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 5 was replaced by a PGK-neo cassette inserted by homologous recombination. Circular transcripts were undetected by RT-PCR analysis of brain and kidney samples obtained from homozygous mutant mice. Ribonuclease protection assays showed that transcripts lacking the targeted exon were present at normal levels in homozygous mutant mice. Corresponding results were obtained by Western blot analysis. (J:50647)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fmn1 Mutation:  33 strains or lines available
Homozygous mutant mice have normal limbs, but display variably penetrant renal aplasia characteristic of other limb deformity mutant alleles (J:50647).
Original:  J:50647 Chao CW, et al., The mouse formin (Fmn) gene: abundant circular RNA transcripts and gene-targeted deletion analysis. Mol Med. 1998 Sep;4(9):614-28
All:  1 reference(s)

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MGI 6.06
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