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Pax5tm3Mbu
Targeted Allele Detail
Nomenclature
Symbol: Pax5tm3Mbu
Name: paired box 5; targeted mutation 3, Meinrad Busslinger
MGI ID: MGI:2386577
Synonyms: Pax5F
Gene: Pax5  Location: Chr4:44524757-44710487 bp, - strand  Genetic Position: Chr4, 23.55 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75504
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 2. Cre-mediated recombination removed the neo cassette and left exon 2 floxed. (J:75504)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pax5 Mutation:  19 strains or lines available
References
Original:  J:75504 Horcher M, et al., Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis. Immunity. 2001 Jun;14(6):779-90
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/04/2020
MGI 6.14
The Jackson Laboratory