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Targeted Allele Detail
Symbol: Polbtm1.1Rsky
Name: polymerase (DNA directed), beta; targeted mutation 1.1, Klaus Rajewsky
MGI ID: MGI:2386536
Synonyms: beta-pol-, polbeta-, PolBetadelta, Polbtm1.1Hua
Gene: Polb  Location: Chr8:22628126-22653435 bp, - strand  Genetic Position: Chr8, 11.42 cM
Germline Transmission:  Earliest citation of germline transmission: J:67942
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThe endogenous promoter and exon 1 were deleted when a floxed region extending from 2 kb upstream of exon 1 through a portion of intron 1 was excised by the in vitro expression of cre recombinase. (J:67942)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Polb Mutation:  3 strains or lines available
Original:  J:67942 Gu H, et al., Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science. 1994 Jul 1;265(5168):103-6
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory