Ackr1^tm1Pogo
Targeted Allele Detail

Summary

• Symbol: Ackr1^tm1Pogo
• Name: atypical chemokine receptor 1 (Duffy blood group); targeted mutation 1, Oscar Pogo
• MGI ID: MGI:2386436
• Synonyms: Darc^-, Dfy^-
• Gene: Ackr1 Location: Chr1:173159457-173161079 bp, - strand Genetic Position: Chr1, 80.33 cM
• Alliance: Ackr1^tm1Pogo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61570
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.2 kb region of the gene containing the 5' untranslated region and exons 1-2 was deleted and replaced with a neomycin resistance cassette via homologous recombination. Homozygous mutant animals lacked gene expression as determined by Northern blot analysis of brain and spleen RNA. (J:61570)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ackr1 Mutation: 22 strains or lines available

References

• Original: J:61570 Luo H, et al., Deletion of the murine Duffy gene (Dfy) reveals that the Duffy receptor is functionally redundant. Mol Cell Biol. 2000 May;20(9):3097-101
• All: 7 reference(s)