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Ackr1tm1Pogo
Targeted Allele Detail
Nomenclature
Symbol: Ackr1tm1Pogo
Name: atypical chemokine receptor 1 (Duffy blood group); targeted mutation 1, Oscar Pogo
MGI ID: MGI:2386436
Synonyms: Darc-, Dfy-
Gene: Ackr1  Location: Chr1:173331886-173333750 bp, - strand  Genetic Position: Chr1, 80.33 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61570
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 2.2 kb region of the gene containing the 5' untranslated region and exons 1-2 was deleted and replaced with a neomycin resistance cassette via homologous recombination. Homozygous mutant animals lacked gene expression as determined by Northern blot analysis of brain and spleen RNA. (J:61570)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ackr1 Mutation:  8 strains or lines available
References
Original:  J:61570 Luo H, et al., Deletion of the murine Duffy gene (Dfy) reveals that the Duffy receptor is functionally redundant. Mol Cell Biol. 2000 May;20(9):3097-101
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory