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Smad4tm2.1Cxd
Targeted Allele Detail
Nomenclature
Symbol: Smad4tm2.1Cxd
Name: SMAD family member 4; targeted mutation 2.1, Chu-Xia Deng
MGI ID: MGI:2386393
Synonyms: Smad4Co, Smad4fl, Smad4flox, Smad4fx(exon8), Smad4loxp, Smadflox
Gene: Smad4  Location: Chr18:73639009-73703780 bp, - strand  Genetic Position: Chr18, 49.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75140
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Smad4 Mutation:  12 strains or lines available
Notes

Phenotypic Similarity to Human Syndrome: Squamous Cell Carcinoma J:203922 in double Kras and Smad4 mutants.

References
Original:  J:75140 Yang X, et al., Generation of Smad4/Dpc4 conditional knockout mice. Genesis. 2002 Feb;32(2):80-1
All:  93 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory