Smad4^tm2.1Cxd
Targeted Allele Detail

Summary

• Symbol: Smad4^tm2.1Cxd
• Name: SMAD family member 4; targeted mutation 2.1, Chu-Xia Deng
• MGI ID: MGI:2386393
• Synonyms: Smad4^Co, Smad4^fl, Smad4^flox, Smad4^fx(exon8), Smad4^loxp, Smad^flox
• Gene: Smad4 Location: Chr18:73772080-73836851 bp, - strand Genetic Position: Chr18, 49.51 cM
• Alliance: Smad4^tm2.1Cxd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75140
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: Exon 8 was left flanked by single loxP sites after the floxed neo cassette was excised by the in vivo expression of cre recombinase. (J:75140)

Generation of the Smad4^tm2.1Cxd allele

Disease models

Expression

In Mice Carrying this Mutation:	113 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	29 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Smad4^tm2.1Cxd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Smad4 Mutation: 43 strains or lines available

References

• Original: J:75140 Yang X, et al., Generation of Smad4/Dpc4 conditional knockout mice. Genesis. 2002 Feb;32(2):80-1
• All: 182 reference(s)