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Smad4tm2.1Cxd
Targeted Allele Detail
Nomenclature
Symbol: Smad4tm2.1Cxd
Name: SMAD family member 4; targeted mutation 2.1, Chu-Xia Deng
MGI ID: MGI:2386393
Synonyms: Smad4Co, Smad4fl, Smad4flox, Smad4fx(exon8), Smad4loxp, Smadflox
Gene: Smad4  Location: Chr18:73639009-73703780 bp, - strand  Genetic Position: Chr18, 49.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75140
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 8 was left flanked by single loxP sites after the floxed neo cassette was excised by the in vivo expression of cre recombinase. (J:75140)
Generation of the Smad4tm2.1Cxd allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 61 assay results
In Structures Affected by this Mutation: 29 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Smad4 Mutation:  13 strains or lines available
References
Original:  J:75140 Yang X, et al., Generation of Smad4/Dpc4 conditional knockout mice. Genesis. 2002 Feb;32(2):80-1
All:  130 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory