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Kcna4tm1Lndn
Targeted Allele Detail
Nomenclature
Symbol: Kcna4tm1Lndn
Name: potassium voltage-gated channel, shaker-related subfamily, member 4; targeted mutation 1, Barry London
MGI ID: MGI:2386331
Synonyms: Kv1.4-
Gene: Kcna4  Location: Chr2:107290639-107298502 bp, + strand  Genetic Position: Chr2, 56.12 cM, cytoband E
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:48415
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of a large part of the coding region with a PGK-neo cassette resulting in the deletion of the N-terminal multimerization domain. Northern blot analysis of brain RNA from homozygous mutant animals detected a truncated transcript, and Western blot analysis failed to detect the 85 kDa protein in the heart or brain. However, a 65 kDa protein was detected that may possibly be another channel protein that cross-reacts with the anti-Kcna4 antibody. (J:48415)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcna4 Mutation:  20 strains or lines available
References
Original:  J:48415 London B, et al., The transient outward current in mice lacking the potassium channel gene Kv1.4. J Physiol. 1998 May 15;509(Pt 1):171-82
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory