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Targeted Allele Detail
Symbol: Igf1rtm1Mhz
Name: insulin-like growth factor I receptor; targeted mutation 1, Martin Holzenberger
MGI ID: MGI:2386327
Synonyms: IGF-IRneo
Gene: Igf1r  Location: Chr7:67952827-68233668 bp, + strand  Genetic Position: Chr7, 37.27 cM
Germline Transmission:  Earliest citation of germline transmission: J:63460
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsExon 3 was flanked by a floxed neo cassette inserted into intron 2 and a single loxP site in intron 3. Several aberrant transcripts involving the splicing of exon 2 to cryptic slice sites in the neo transgene were identified by RT-PCR and sequence analyses. Further analysis indicated that the readthrough of the neo transgene will result in functional ablation due to truncation or the inclusion of a random neo fragment. Mice carrying this allele were crossed with transgenic mice expressing cre recombinase via the EIIa promoter to generate Igf1rtm1.1Mhz and Igf1rtm1.2Mhz. (J:63460)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igf1r Mutation:  49 strains or lines available
Original:  J:63460 Holzenberger M, et al., A targeted partial invalidation of the insulin-like growth factor I receptor gene in mice causes a postnatal growth deficit. Endocrinology. 2000 Jul;141(7):2557-66
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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