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Targeted Allele Detail
Symbol: Krt6atm1Der
Name: keratin 6A; targeted mutation 1, Dennis R Roop
MGI ID: MGI:2386313
Synonyms: MK6a-
Gene: Krt6a  Location: Chr15:101689932-101694307 bp, - strand  Genetic Position: Chr15, 56.97 cM
Germline Transmission:  Earliest citation of germline transmission: J:63037
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire coding region of the gene was replaced with a neomycin resistance cassette, Hprt minigene, and loxP site. Homozygous mutant animals lacked gene expression and protein production as shown by RNase protection assay and Western blot analysis of whole skin samples, respectively. (J:63037)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Krt6a Mutation:  0 strains or lines available
Original:  J:63037 Wojcik SM, et al., Delayed wound healing in keratin 6a knockout mice. Mol Cell Biol. 2000 Jul;20(14):5248-55
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.0
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