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Targeted Allele Detail
Symbol: Slc6a3tm1Mca
Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 1, Marc G Caron
MGI ID: MGI:2386303
Synonyms: DAT-, DAT-KO
Gene: Slc6a3  Location: Chr13:73536747-73578672 bp, + strand  Genetic Position: Chr13, 40.1 cM
Germline Transmission:  Earliest citation of germline transmission: J:31328
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsThe gene was disrupted by insertion of a neomycin resistance cassette into a coding exon via homologous recombination. Gene expression is absent in the ventral tegmental area (VTA) and dopaminergic cells of the substantia nigra pars compacta (SNC) in homozygous animals as shown by in situ hybridization analysis. (J:31328)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc6a3 Mutation:  43 strains or lines available
Original:  J:31328 Giros B, et al., Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature. 1996 Feb 15;379(6566):606-12
All:  84 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory