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Targeted Allele Detail
Symbol: Scgb1a1tm1Abm
Name: secretoglobin, family 1A, member 1 (uteroglobin); targeted mutation 1, Anil B Mukherjee
MGI ID: MGI:2386295
Synonyms: CC10-deficient, UG-
Gene: Scgb1a1  Location: Chr19:9083636-9087958 bp, - strand  Genetic Position: Chr19, 6.05 cM, cytoband A
Germline Transmission:  Earliest citation of germline transmission: J:40748
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA portion of exon 2 and all of exon 3 were replaced with a neomycin selection cassette. Transcript was undetected by RT-PCR analysis of total lung RNA obtained from homozygous mutant mice. The absence of protein was verified by Western blot analysis of lung lysates and immunohistochemical analysis of bronchiolar epithelial cells. Analysis of prostate and uterine tissue obtained from homozygous mutant mice yielded corroborative results. (J:40748)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scgb1a1 Mutation:  17 strains or lines available
Original:  J:40748 Zhang Z, et al., Severe fibronectin-deposit renal glomerular disease in mice lacking uteroglobin. Science. 1997 May 30;276(5317):1408-12
All:  9 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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