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Targeted Allele Detail
Symbol: Ivltm1Dji
Name: involucrin; targeted mutation 1, Philippe Djian
MGI ID: MGI:2386285
Synonyms: inv-
Gene: Ivl  Location: Chr3:92570902-92573735 bp, - strand  Genetic Position: Chr3, 40.14 cM
Germline Transmission:  Earliest citation of germline transmission: J:65192
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire coding region of the endogenous gene was replaced with a neomycin selection cassette via homologous recombination. Northern blot analysis of total RNA isolated from skin samples showed an absence of transcript in homozygous mutant mice. A lack of protein was confirmed by both Western blot analysis and in situ hybridization. (J:65192)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ivl Mutation:  13 strains or lines available
Original:  J:65192 Djian P, et al., Targeted ablation of the murine involucrin gene. J Cell Biol. 2000 Oct 16;151(2):381-8
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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