Tnfsf11tm1Ywc
Targeted Allele Detail
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Symbol: |
Tnfsf11tm1Ywc |
Name: |
tumor necrosis factor (ligand) superfamily, member 11; targeted mutation 1, Yongwon Choi |
MGI ID: |
MGI:2386263 |
Synonyms: |
Rankl-, RANKL KO |
Gene: |
Tnfsf11 Location: Chr14:78514886-78545483 bp, - strand Genetic Position: Chr14, 41.26 cM
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Alliance: |
Tnfsf11tm1Ywc page
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Skeletal growth abnormalities in Tnfsf11tm1Ywc/Tnfsf11tm1Ywc mice
Show the 4 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:64737
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Parent Cell Line: |
E14.1 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin selection cassette replaced nucleotides 699 through 1089 from exon 5 in addition to 1123 bp of the 3' untranslated region. The deleted region encoded amino acids 185 through 316.
(J:64737)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Tnfsf11 Mutation: |
30 strains or lines available
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Original: |
J:64737 Kim N, et al., Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene. Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10905-10 |
All: |
19 reference(s) |
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