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Targeted Allele Detail
Symbol: Tnfsf11tm1Ywc
Name: tumor necrosis factor (ligand) superfamily, member 11; targeted mutation 1, Yongwon Choi
MGI ID: MGI:2386263
Synonyms: Rankl-, RANKL KO
Gene: Tnfsf11  Location: Chr14:78277446-78308043 bp, - strand  Genetic Position: Chr14, 41.26 cM
Skeletal growth abnormalities in Tnfsf11tm1Ywc/Tnfsf11tm1Ywc mice

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:64737
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced nucleotides 699 through 1089 from exon 5 in addition to 1123 bp of the 3' untranslated region. The deleted region encoded amino acids 185 through 316. (J:64737)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfsf11 Mutation:  21 strains or lines available
Original:  J:64737 Kim N, et al., Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene. Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10905-10
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory