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Targeted Allele Detail
Symbol: Tnfsf11tm1Ywc
Name: tumor necrosis factor (ligand) superfamily, member 11; targeted mutation 1, Yongwon Choi
MGI ID: MGI:2386263
Synonyms: Rankl-, RANKL KO
Gene: Tnfsf11  Location: Chr14:78514886-78545483 bp, - strand  Genetic Position: Chr14, 41.26 cM
Skeletal growth abnormalities in Tnfsf11tm1Ywc/Tnfsf11tm1Ywc mice

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:64737
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced nucleotides 699 through 1089 from exon 5 in addition to 1123 bp of the 3' untranslated region. The deleted region encoded amino acids 185 through 316. (J:64737)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 25 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfsf11 Mutation:  26 strains or lines available
Original:  J:64737 Kim N, et al., Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene. Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10905-10
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory