Tnfsf11^tm1Ywc
Targeted Allele Detail

Summary

• Symbol: Tnfsf11^tm1Ywc
• Name: tumor necrosis factor (ligand) superfamily, member 11; targeted mutation 1, Yongwon Choi
• MGI ID: MGI:2386263
• Synonyms: Rankl-, RANKL KO
• Gene: Tnfsf11 Location: Chr14:78514886-78545483 bp, - strand Genetic Position: Chr14, 41.26 cM
• Alliance: Tnfsf11^tm1Ywc page

Skeletal growth abnormalities in Tnfsf11^tm1Ywc/Tnfsf11^tm1Ywc mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64737
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced nucleotides 699 through 1089 from exon 5 in addition to 1123 bp of the 3' untranslated region. The deleted region encoded amino acids 185 through 316. (J:64737)

Disease models

Expression

In Structures Affected by this Mutation:

23 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfsf11 Mutation: 30 strains or lines available

References

• Original: J:64737 Kim N, et al., Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene. Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10905-10
• All: 19 reference(s)