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Rasgrp1tm1Jstn
Targeted Allele Detail
Nomenclature
Symbol: Rasgrp1tm1Jstn
Name: RAS guanyl releasing protein 1; targeted mutation 1, James C Stone
MGI ID: MGI:2386261
Synonyms: RasGRP1-
Gene: Rasgrp1  Location: Chr2:117279993-117343001 bp, - strand  Genetic Position: Chr2, 59.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65115
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P3/J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 2 was disrupted by the insertion of a cassette containing both Beta-galactosidase and neomycin resistance genes. While the translation of a fusion protein containing residues 1 through 16 of the endogenous joined to the Beta-galactosidase protein was expected, such a polypeptide was undetected by Western blot analysis of thymus and spleen extracts obtained from homozygous mutant mice. (J:65115)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rasgrp1 Mutation:  21 strains or lines available
Notes
ES cell line = NX1.
References
Original:  J:65115 Dower NA, et al., RasGRP is essential for mouse thymocyte differentiation and TCR signaling. Nat Immunol. 2000 Oct;1(4):317-21
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory