Mmp2tm1Ito
Targeted Allele Detail
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Symbol: |
Mmp2tm1Ito |
Name: |
matrix metallopeptidase 2; targeted mutation 1, Shigeyoshi Itohara |
MGI ID: |
MGI:2386252 |
Synonyms: |
MMP-2 -, MMP2-, MMP-2 KO |
Gene: |
Mmp2 Location: Chr8:92827291-92853420 bp, + strand Genetic Position: Chr8, 44.99 cM
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Cardiac neutrophil accumulation post-myocardial infraction is normalized in Timp4tm1Vuo/Timp4tm1Vuo Mmp2tm1Ito/Mmp2tm1Ito mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:42742
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd |
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: 5.9 kb of the gene including exon 1 was replaced with a PGK-neo cassette via homologous recombination. Absence of protein activity in the brain, lungs, and kidneys of homozygous mutant animals was confirmed by gelatin zymography.
(J:42742)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:42742 Itoh T, et al., Unaltered secretion of beta-amyloid precursor protein in gelatinase A (matrix metalloproteinase 2)-deficient mice. J Biol Chem. 1997 Sep 5;272(36):22389-92 |
All: |
105 reference(s) |
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