Mmp2^tm1Ito
Targeted Allele Detail

Nomenclature

Symbol:	Mmp2^tm1Ito
Name:	matrix metallopeptidase 2; targeted mutation 1, Shigeyoshi Itohara
MGI ID:	MGI:2386252
Synonyms:	MMP-2 -, MMP2^-, MMP-2 KO
Gene:	Mmp2  Location: Chr8:92827328-92853417 bp, + strand  Genetic Position: Chr8, 44.99 cM

Cardiac neutrophil accumulation post-myocardial infraction is normalized in Timp4^tm1Vuo/Timp4^tm1Vuo Mmp2^tm1Ito/Mmp2^tm1Ito mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

Germline Transmission:	Earliest citation of germline transmission: J:42742
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: 5.9 kb of the gene including exon 1 was replaced with a PGK-neo cassette via homologous recombination. Absence of protein activity in the brain, lungs, and kidneys of homozygous mutant animals was confirmed by gelatin zymography. (J:42742)

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mmp2 Mutation:	2 strains or lines available

References

Original:	J:42742 Itoh T, et al., Unaltered secretion of beta-amyloid precursor protein in gelatinase A (matrix metalloproteinase 2)-deficient mice. J Biol Chem. 1997 Sep 5;272(36):22389-92
All:	90 reference(s)