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Targeted Allele Detail
Symbol: Mmp2tm1Ito
Name: matrix metallopeptidase 2; targeted mutation 1, Shigeyoshi Itohara
MGI ID: MGI:2386252
Synonyms: MMP-2 -, MMP2-, MMP-2 KO
Gene: Mmp2  Location: Chr8:92827291-92853420 bp, + strand  Genetic Position: Chr8, 44.99 cM
Cardiac neutrophil accumulation post-myocardial infraction is normalized in Timp4tm1Vuo/Timp4tm1Vuo Mmp2tm1Ito/Mmp2tm1Ito mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:42742
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation details5.9 kb of the gene including exon 1 was replaced with a PGK-neo cassette via homologous recombination. Absence of protein activity in the brain, lungs, and kidneys of homozygous mutant animals was confirmed by gelatin zymography. (J:42742)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 20 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mmp2 Mutation:  8 strains or lines available
Original:  J:42742 Itoh T, et al., Unaltered secretion of beta-amyloid precursor protein in gelatinase A (matrix metalloproteinase 2)-deficient mice. J Biol Chem. 1997 Sep 5;272(36):22389-92
All:  107 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory