Mmp2^tm1Ito
Targeted Allele Detail

Nomenclature

• Symbol: Mmp2^tm1Ito
• Name: matrix metallopeptidase 2; targeted mutation 1, Shigeyoshi Itohara
• MGI ID: MGI:2386252
• Synonyms: MMP-2 -, MMP2^-, MMP-2 KO
• Gene: Mmp2 Location: Chr8:92827291-92853420 bp, + strand Genetic Position: Chr8, 44.99 cM

Cardiac neutrophil accumulation post-myocardial infraction is normalized in Timp4^tm1Vuo/Timp4^tm1Vuo Mmp2^tm1Ito/Mmp2^tm1Ito mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42742
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 5.9 kb of the gene including exon 1 was replaced with a PGK-neo cassette via homologous recombination. Absence of protein activity in the brain, lungs, and kidneys of homozygous mutant animals was confirmed by gelatin zymography. (J:42742)

Expression

In Structures Affected by this Mutation:

20 anatomical structures

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mmp2 Mutation: 8 strains or lines available

References

• Original: J:42742 Itoh T, et al., Unaltered secretion of beta-amyloid precursor protein in gelatinase A (matrix metalloproteinase 2)-deficient mice. J Biol Chem. 1997 Sep 5;272(36):22389-92
• All: 107 reference(s)