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Mmp14tm1Ktry
Targeted Allele Detail
Nomenclature
Symbol: Mmp14tm1Ktry
Name: matrix metallopeptidase 14 (membrane-inserted); targeted mutation 1, Karl Tryggvason
MGI ID: MGI:2386246
Synonyms: Mmp13tm1Ktry
Gene: Mmp14  Location: Chr14:54431612-54441265 bp, + strand  Genetic Position: Chr14, 27.79 cM
Histology and immunohistology of growth zones in distal femur of Mmp14tm1Ktry/Mmp14tm1Ktry mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61685
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details0.5 kb of the gene including part of exon 4 was replaced with a neomycin resistance cassette via homologous recombination. Northern blot analysis of lung and heart from homozygous mutant mice confirmed the absence of gene expression. (J:61685)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mmp14 Mutation:  14 strains or lines available
References
Original:  J:61685 Zhou Z, et al., Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4052-7
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory