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Nppbtm1Yog
Targeted Allele Detail
Nomenclature
Symbol: Nppbtm1Yog
Name: natriuretic peptide type B; targeted mutation 1, Yoshihiro Ogawa
MGI ID: MGI:2386215
Synonyms: BNP-, Nppb-
Gene: Nppb  Location: Chr4:147985788-147987205 bp, + strand  Genetic Position: Chr4, 78.57 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61680
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exons 1-2 with a neomycin resistance cassette via homologous recombination. Gene transcripts and protein product were not detectable in the hearts of homozygous mutant animals. (J:61680)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nppb Mutation:  4 strains or lines available
References
Original:  J:61680 Tamura N, et al., Cardiac fibrosis in mice lacking brain natriuretic peptide. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4239-44
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory