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Pdcd1tm1Hon
Targeted Allele Detail
Summary
Symbol: Pdcd1tm1Hon
Name: programmed cell death 1; targeted mutation 1, Tasuku Honjo
MGI ID: MGI:2386184
Synonyms: PD-1-
Gene: Pdcd1  Location: Chr1:93966027-93980278 bp, - strand  Genetic Position: Chr1, 47.47 cM
Alliance: Pdcd1tm1Hon page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50688
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA region encoding both transmembrane and cytoplasmic domains was deleted by the replacement of sequence extending from within exon 3 through a portion of exon 4 with a neomycin selection cassette. Flow cytometric analysis of cultured cells derived from homozygous mutant mice showed a lack of protein expression on the cell surface. (J:50688)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Pdcd1 Mutation:  69 strains or lines available
References
Original:  J:50688 Nishimura H, et al., Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. Int Immunol. 1998 Oct;10(10):1563-72
All:  120 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory