Igfals^tm1Yrb
Targeted Allele Detail

Summary

• Symbol: Igfals^tm1Yrb
• Name: insulin-like growth factor binding protein, acid labile subunit; targeted mutation 1, Yves R Boisclair
• MGI ID: MGI:2386180
• Synonyms: ALSKO
• Gene: Igfals Location: Chr17:25096818-25100985 bp, + strand Genetic Position: Chr17, 12.53 cM, cytoband A2-A3
• Alliance: Igfals^tm1Yrb page

Igf1^tm1Dlr/Igf1^tm1Dlr Igfals^tm1Yrb/Igfals^tm1Yrb Tg(Alb1-cre)1Dlr/? mice exhibit reduced growth plate height

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:62710
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sequences encoding the first 435 amino acids (including 16 out of 19 leucine repeats) corresponding to exon 1, intron 1, and part of exon 2 were replaced by a neomycin resistance cassette. Northern blot analysis showed an absence of gene transcripts in liver and kidneys of homozygous mutant animals. Plasma proteins from homozygous animals were unable to form cross-linking complexes which is consistent with deletion of the 16 leucine repeats. (J:62710)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igfals Mutation: 33 strains or lines available

References

• Original: J:62710 Ueki I, et al., Inactivation of the acid labile subunit gene in mice results in mild retardation of postnatal growth despite profound disruptions in the circulating insulin-like growth factor system. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6868-73
• All: 10 reference(s)