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Targeted Allele Detail
Symbol: Mmp12tm1Sds
Name: matrix metallopeptidase 12; targeted mutation 1, Steven D Shapiro
MGI ID: MGI:2386174
Synonyms: MME-, Mmp12-, MMP-12-
Gene: Mmp12  Location: Chr9:7344397-7360461 bp, + strand  Genetic Position: Chr9, 2.46 cM
Germline Transmission:  Earliest citation of germline transmission: J:32902
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of the majority of exon 2 with a PGK-neo cassette via homologous recombination. Gene transcription and protein production was absent in homozygous mutant animals as demonstrated by Northern and Western blot analysis of peritoneal macrophages and peritoneal fluid. (J:32902)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mmp12 Mutation:  6 strains or lines available
Original:  J:32902 Shipley JM, et al., Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice. Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3942-6
All:  55 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory