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Targeted Allele Detail
Symbol: Ttpatm1Hsz
Name: tocopherol (alpha) transfer protein; targeted mutation 1, Hiroshi Suzuki
MGI ID: MGI:2386172
Synonyms: alpha-TTP-, alpha-Ttptm1Csk, Ttpa-
Gene: Ttpa  Location: Chr4:20007938-20030785 bp, + strand  Genetic Position: Chr4, 7.76 cM, cytoband A3
Histological findings indicating neurodegeneration in Ttpatm1Hsz/Ttpatm1Hsz mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:67046
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1, containing the translational start codon, was replaced with a neomycin selection cassette. Transcript was undetected by Northern blot analysis of liver samples obtained from homozygous mutant mice. (J:67046)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 11 assay results
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ttpa Mutation:  13 strains or lines available
ES cell lines = AB2.2 and A3-1. Mice from line L236 were derived from AB2.2 ES cells (129S7/SvEvBrd-Hprtb-m2). Mice from line C229 were derived from A3-1 ES cells (129X1/SvJ).
Original:  J:67046 Jishage K, et al., Alpha-tocopherol transfer protein is important for the normal development of placental labyrinthine trophoblasts in mice. J Biol Chem. 2001 Jan 19;276(3):1669-72
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
The Jackson Laboratory