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Hsd11b2tm1Yko
Targeted Allele Detail
Nomenclature
Symbol: Hsd11b2tm1Yko
Name: hydroxysteroid 11-beta dehydrogenase 2; targeted mutation 1, Yuri V Kotelevtsev
MGI ID: MGI:2386169
Synonyms: 11Beta-HSD2-
Gene: Hsd11b2  Location: Chr8:105518746-105523984 bp, + strand  Genetic Position: Chr8, 53.04 cM
Hyperplasia and hypertrophy of the distal renal tubular epithelium in Hsd11b2tm1Yko/Hsd11b2tm1Yko mice

Show the 2 image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53391
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (knock-out)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 56 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hsd11b2 Mutation:  1 strain or line available
References
Original:  J:53391 Kotelevtsev Y, et al., Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2. J Clin Invest. 1999 Mar;103(5):683-9
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory