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Targeted Allele Detail
Symbol: Hsd11b2tm1Yko
Name: hydroxysteroid 11-beta dehydrogenase 2; targeted mutation 1, Yuri V Kotelevtsev
MGI ID: MGI:2386169
Synonyms: 11Beta-HSD2-
Gene: Hsd11b2  Location: Chr8:105518755-105523988 bp, + strand  Genetic Position: Chr8, 53.04 cM
Hyperplasia and hypertrophy of the distal renal tubular epithelium in Hsd11b2tm1Yko/Hsd11b2tm1Yko mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:53391
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2 through 5 were replaced by a neomycin selection cassette. Transcript was undetected in homozygous mutant mice via Northern blot analysis of total kidney RNA. (J:53391)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 56 assay results
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hsd11b2 Mutation:  12 strains or lines available
Original:  J:53391 Kotelevtsev Y, et al., Hypertension in mice lacking 11beta-hydroxysteroid dehydrogenase type 2. J Clin Invest. 1999 Mar;103(5):683-9
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory