Lilrb4a^tm1Eol
Targeted Allele Detail

Summary

• Symbol: Lilrb4a^tm1Eol
• Name: leukocyte immunoglobulin-like receptor, subfamily B, member 4A; targeted mutation 1, Eric O Long
• MGI ID: MGI:2386122
• Synonyms: gp49B⁰
• Gene: Lilrb4a Location: Chr10:51367052-51372707 bp, + strand Genetic Position: Chr10, 25.5 cM, cytoband B4
• Alliance: Lilrb4a^tm1Eol page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64504
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 220 bp fragment of the gene containing exon 1 was replaced with a floxed neomycin cassette via homologous recombination. Protein expression was absent in bone marrow-derived mast cells (BMMC) and natural killer cells (NK) from homozygous mutant animals as determined by immunoprecipitation immunoblot assay. (J:64504)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lilrb4a Mutation: 28 strains or lines available

References

• Original: J:64504 Rojo S, et al., Natural killer cells and mast cells from gp49B null mutant mice are functional. Mol Cell Biol. 2000 Oct;20(19):7178-82
• All: 3 reference(s)