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Rarbtm2.1Ipc
Targeted Allele Detail
Nomenclature
Symbol: Rarbtm2.1Ipc
Name: retinoic acid receptor, beta; targeted mutation 2.1, Pierre Chambon
MGI ID: MGI:2386109
Synonyms: RARbetaL-
Gene: Rarb  Location: Chr14:16430842-16575472 bp, - strand  Genetic Position: Chr14, 7.08 cM, cytoband A1-A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75134
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe floxed fragment containing exons 9 and and 10 was excised from Rarbtm2Ipc by the ubiquitous in vivo expression of cre recombinase. The deletion eliminated the majority of the ligand binding domain and introduced a frameshift mutation. Neither isoform produced by the endogenous gene was detected in homozygous mutant mice via immunoblot analysis. (J:75134)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rarb Mutation:  15 strains or lines available
References
Original:  J:75134 Chapellier B, et al., A conditional floxed (loxP-flanked) allele for the retinoic acid receptor beta (RARbeta) gene. Genesis. 2002 Feb;32(2):91-4
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory