About   Help   FAQ
Rarbtm2.1Ipc
Targeted Allele Detail
Nomenclature
Symbol: Rarbtm2.1Ipc
Name: retinoic acid receptor, beta; targeted mutation 2.1, Pierre Chambon
MGI ID: MGI:2386109
Synonyms: RARbetaL-
Gene: Rarb  Location: Chr14:16430842-16575472 bp, - strand  Genetic Position: Chr14, 7.08 cM, cytoband A1-A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75134
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe floxed fragment containing exons 9 and and 10 was excised from Rarbtm2Ipc by the ubiquitous in vivo expression of cre recombinase. The deletion eliminated the majority of the ligand binding domain and introduced a frameshift mutation. Neither isoform produced by the endogenous gene was detected in homozygous mutant mice via immunoblot analysis. (J:75134)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rarb Mutation:  17 strains or lines available
References
Original:  J:75134 Chapellier B, et al., A conditional floxed (loxP-flanked) allele for the retinoic acid receptor beta (RARbeta) gene. Genesis. 2002 Feb;32(2):91-4
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/20/2017
MGI 6.10
The Jackson Laboratory