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Targeted Allele Detail
Symbol: Plcg2tm1Jni
Name: phospholipase C, gamma 2; targeted mutation 1, James N Ihle
MGI ID: MGI:2386100
Synonyms: PLCgamma2-
Gene: Plcg2  Location: Chr8:117498291-117635140 bp, + strand  Genetic Position: Chr8, 64.26 cM
Plcg2tm1Jni/Plcg2tm1Jni mice are protected from mBSA-induced arthritis

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:63679
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 3.8 kb region of the gene containing exon 2 was replaced with a neomycin resistance gene via homologous recombination. Spleen extracts from homozygous mutant animals did not contain protein product as determined by immunoprecipitation and Western blot analysis using antibodies directed against the C-terminus of the protein. (J:63679)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Plcg2 Mutation:  23 strains or lines available
Original:  J:63679 Wang D, et al., Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors. Immunity. 2000 Jul;13(1):25-35
All:  35 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.04
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