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Nfe2l2tm1Ney
Targeted Allele Detail
Nomenclature
Symbol: Nfe2l2tm1Ney
Name: nuclear factor, erythroid derived 2, like 2; targeted mutation 1, Paul A Ney
MGI ID: MGI:2385960
Synonyms: Nrf-2 (-)
Gene: Nfe2l2  Location: Chr2:75675513-75704641 bp, - strand  Genetic Position: Chr2, 44.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47440
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette was inserted into exon 5, into sequences encoding the BZIP domain. Northern blot analysis demonstrated that an aberrant transcript was expressed from this allele. However, immunoprecipitation experiments confirmed that no detectable protein was made. (J:47440)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfe2l2 Mutation:  70 strains or lines available
References
Original:  J:47440 Martin F, et al., Erythroid maturation and globin gene expression in mice with combined deficiency of NF-E2 and nrf-2. Blood. 1998 May 1;91(9):3459-66
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory