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Targeted Allele Detail
Symbol: Fosbtm1Brv
Name: FBJ osteosarcoma oncogene B; targeted mutation 1, Rodrigo Bravo
MGI ID: MGI:2385943
Synonyms: fosB-
Gene: Fosb  Location: Chr7:19302696-19310051 bp, - strand  Genetic Position: Chr7, 9.56 cM, cytoband A2-B1
Germline Transmission:  Earliest citation of germline transmission: J:33415
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of a 0.9 kb region including most of exon 2 to intron 3 (nucleotides 3460-4382) with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was verified by immunohistochemical analysis of the serous glands. (J:33415)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fosb Mutation:  12 strains or lines available
Original:  J:33415 Gruda MC, et al., Expression of FosB during mouse development: normal development of FosB knockout mice. Oncogene. 1996 May 16;12(10):2177-85
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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