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Vamp3tm1Jepn
Targeted Allele Detail
Nomenclature
Symbol: Vamp3tm1Jepn
Name: vesicle-associated membrane protein 3; targeted mutation 1, Jeffrey E Pessin
MGI ID: MGI:2385941
Synonyms: cebko, cellubrevin/VAMP3-
Gene: Vamp3  Location: Chr4:151047300-151057963 bp, - strand  Genetic Position: Chr4, 81.53 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67364
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details7.8 kb of sequence were replaced with a neomycin selection cassette. The deleted region included exon 2, which contains the guanosine of the translational start codon, and exon 3, whcih encodes the entire coiled-coil domain. Western blot analysis of homozygous mutant mice showed an absence of the normal protein product. (J:67364)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 24 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vamp3 Mutation:  6 strains or lines available
References
Original:  J:67364 Yang C, et al., VAMP3 null mice display normal constitutive, insulin- and exercise-regulated vesicle trafficking. Mol Cell Biol. 2001 Mar;21(5):1573-80
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory