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Targeted Allele Detail
Symbol: Nr2f1tm1Mjts
Name: nuclear receptor subfamily 2, group F, member 1; targeted mutation 1, Ming-Jer Tsai
MGI ID: MGI:2385930
Synonyms: COUP-TFI-, Coup-tfI mutant, mCOUP-TFI mutant
Gene: Nr2f1  Location: Chr13:78337090-78346992 bp, - strand  Genetic Position: Chr13, 41.38 cM
Alliance: Nr2f1tm1Mjts page
Germline Transmission:  Earliest citation of germline transmission: J:42259
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsSequence encoding the amino terminus, the DNA binding domain, and a portion of the ligand binding domain was deleted by the insertion of neomycin selection cassette. Normal transcript was not detected by Northern blot analysis of homozygous mutant embryos. (J:42259)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 18 assay results
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr2f1 Mutation:  13 strains or lines available
Original:  J:42259 Qiu Y, et al., Null mutation of mCOUP-TFI results in defects in morphogenesis of the glossopharyngeal ganglion, axonal projection, and arborization. Genes Dev. 1997 Aug 1;11(15):1925-37
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory