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Targeted Allele Detail
Symbol: Nfe2l1tm1Ywk
Name: nuclear factor, erythroid derived 2,-like 1; targeted mutation 1, Yuet Wai Kan
MGI ID: MGI:2385929
Synonyms: Nrf-1 -
Gene: Nfe2l1  Location: Chr11:96817431-96829955 bp, - strand  Genetic Position: Chr11, 60.12 cM, cytoband D-E
Abnormal development of Nfe2l1tm1Ywk/Nfe2l1tm1Ywk Nfe2l2tm1Ywk/Nfe2l2tm1Ywk embryos with increased apoptosis

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:46990
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted into the terminal exon which encodes the DNA binding and leucine zipper domains. Northern blot and RT-PCR analysis demonstrated that a mutant 7 kb transcript was expressed from this allele, but immunoblot analysis confirmed that no detectable protein was encoded by this allele. (J:46990)
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfe2l1 Mutation:  8 strains or lines available
Original:  J:46990 Chan JY, et al., Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice. EMBO J. 1998 Mar 16;17(6):1779-87
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory