About   Help   FAQ
Targeted Allele Detail
Symbol: Nfe2l1tm1Ywk
Name: nuclear factor, erythroid derived 2,-like 1; targeted mutation 1, Yuet Wai Kan
MGI ID: MGI:2385929
Synonyms: Nrf-1 -, Nrf1rPGK-neo
Gene: Nfe2l1  Location: Chr11:96817431-96829955 bp, - strand  Genetic Position: Chr11, 60.12 cM, cytoband D-E
Abnormal development of Nfe2l1tm1Ywk/Nfe2l1tm1Ywk Nfe2l2tm1Ywk/Nfe2l2tm1Ywk embryos with increased apoptosis

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:46990
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted into the terminal exon which encodes the DNA binding and leucine zipper domains. Northern blot and RT-PCR analysis demonstrated that a mutant 7 kb transcript was expressed from this allele, but immunoblot analysis confirmed that no detectable protein was encoded by this allele. (J:46990)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfe2l1 Mutation:  16 strains or lines available
Original:  J:46990 Chan JY, et al., Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice. EMBO J. 1998 Mar 16;17(6):1779-87
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.11
The Jackson Laboratory