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Targeted Allele Detail
Symbol: Nfe2l2tm1Ywk
Name: nuclear factor, erythroid derived 2, like 2; targeted mutation 1, Yuet Wai Kan
MGI ID: MGI:2385926
Synonyms: NRF2-, Nrf2 KO
Gene: Nfe2l2  Location: Chr2:75505857-75534985 bp, - strand  Genetic Position: Chr2, 44.75 cM
Abnormal development of Nfe2l1tm1Ywk/Nfe2l1tm1Ywk Nfe2l2tm1Ywk/Nfe2l2tm1Ywk embryos with increased apoptosis

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:37053
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 4.2 kb segment, includind part of exon 4 and all of exon 5, was replaced by an in-frame lacZ gene followed by a neomycin selection cassette. Northern blot analysis on RNA derived from various tissues confirmed that a fusion transcript was detectable in intestine of homozygous mice, but no wild-type transcript was detectable in any tissue. However, no fusion protein was detected by histochemical staining in any adult tissue. (J:37053)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 9 assay results
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Nfe2l2 Mutation:  84 strains or lines available
Original:  J:37053 Chan K, et al., NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13943-8
All:  159 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory