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Targeted Allele Detail
Symbol: Nfe2l2tm1Mym
Name: nuclear factor, erythroid derived 2, like 2; targeted mutation 1, Masayuki Yamamoto
MGI ID: MGI:2385925
Synonyms: Nfe2l2tm1Yin, nrf2 (-), Nrf2-
Gene: Nfe2l2  Location: Chr2:75505857-75534985 bp, - strand  Genetic Position: Chr2, 44.75 cM
Germline Transmission:  Earliest citation of germline transmission: J:41943
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA lacZ gene followed by a neomycin selection cassette was inserted in-frame into exon 5, and a 1.2 kb segment containing the rest of the exon 5 coding sequences was deleted. Northern blot analysis confirmed that no wild-type transcript is expressed from this allele. (J:41943)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 16 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Nfe2l2 Mutation:  85 strains or lines available
Original:  J:41943 Itoh K, et al., An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem Biophys Res Commun. 1997 Jul 18;236(2):313-22
All:  302 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory