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Myl2tm1(cre)Krc
Targeted Allele Detail
Summary
Symbol: Myl2tm1(cre)Krc
Name: myosin, light polypeptide 2, regulatory, cardiac, slow; targeted mutation 1, Kenneth R Chien
MGI ID: MGI:2385922
Synonyms: MLC-2v -, Mlc2v-cre, MLC2v-cre, MLC2vcreKI
Gene: Myl2  Location: Chr5:122239014-122251535 bp, + strand  Genetic Position: Chr5, Syntenic
Alliance: Myl2tm1(cre)Krc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45125
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Myl2tm1(cre)Krc expression driven by 1 gene
 
Mutation detailsPart of exon 1 and all of exon 2 were replaced with a cre gene and a floxed PGK-neo-tk cassette via homologous recombination. Western blot analysis showed that homozygous embryos did not express Myl2 protein product. The knocked in cre gene is expressed by the Myl2 promoter in ventricular tissue starting at day E7.5. (J:45125)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Myl2 (mouse)
Summary of all recombinase alleles driven by Myl2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 25 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Myl2 Mutation:  22 strains or lines available
References
Original:  J:45125 Chen J, et al., Selective requirement of myosin light chain 2v in embryonic heart function. J Biol Chem. 1998 Jan 9;273(2):1252-6
All:  137 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory