Mpo^tm1Lus
Targeted Allele Detail

Summary

• Symbol: Mpo^tm1Lus
• Name: myeloperoxidase; targeted mutation 1, Aldons J Lusis
• MGI ID: MGI:2385836
• Gene: Mpo Location: Chr11:87684610-87695238 bp, + strand Genetic Position: Chr11, 52.22 cM, cytoband C
• Alliance: Mpo^tm1Lus page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67586
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 7, which includes sequence involved in heme binding, was disrupted by the insertion of a neomycin selection cassette and a premature stop codon, which precludes the translation of sequence encoding the heavy chain. Northern and Western blot analyses of bone marrow confirmed the absence of transcript and protein in homozygous mutant mice. (J:67586)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mpo Mutation: 54 strains or lines available

References

• Original: J:67586 Brennan ML, et al., Increased atherosclerosis in myeloperoxidase-deficient mice. J Clin Invest. 2001 Feb;107(4):419-30
• All: 49 reference(s)