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Targeted Allele Detail
Symbol: Neurod2tm1Tap
Name: neurogenic differentiation 2; targeted mutation 1, Steven J Tapscott
MGI ID: MGI:2385828
Gene: Neurod2  Location: Chr11:98325415-98329645 bp, - strand  Genetic Position: Chr11, 61.75 cM
Germline Transmission:  Earliest citation of germline transmission: J:69606
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire coding region of the gene was replaced with an in-frame lacZ gene followed by a loxP flanked neomycin selection cassette. The neomycin selection cassette was removed in ES cells by transient Cre expression prior to the production of chimeric mice. Northern blot analysis on RNA derived from brain of homozygous mice demonstrated that no detectable transcript was expressed from this allele. (J:69606)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Neurod2 Mutation:  15 strains or lines available
Original:  J:69606 Olson JM, et al., NeuroD2 is necessary for development and survival of central nervous system neurons. Dev Biol. 2001 Jun 1;234(1):174-87
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory