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Neurod1tm1Jle
Targeted Allele Detail
Nomenclature
Symbol: Neurod1tm1Jle
Name: neurogenic differentiation 1; targeted mutation 1, Jacqueline E Lee
MGI ID: MGI:2385826
Synonyms: ND -, NeuroD1:lacZ, Neurod1tmAK71(lacZ)Jle, Neurod1Z
Gene: Neurod1  Location: Chr2:79452637-79456636 bp, - strand  Genetic Position: Chr2, 47.58 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74715
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA lacZ-neoR cassette replaced the second exon including the entire coding region. A beta-galactosidase fusion protein is expressed from this allele that reflects the endogenous gene expression pattern. (J:74715)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Neurod1 Mutation:  18 strains or lines available
References
Original:  J:74715 Miyata T, et al., NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus. Genes Dev. 1999 Jul 1;13(13):1647-52
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory