Neurod1^tm1Jle
Targeted Allele Detail

Summary

• Symbol: Neurod1^tm1Jle
• Name: neurogenic differentiation 1; targeted mutation 1, Jacqueline E Lee
• MGI ID: MGI:2385826
• Synonyms: ND -, NeuroD1:lacZ, Neurod1^{tmAK71(lacZ)Jle}, Neurod1^Z
• Gene: Neurod1 Location: Chr2:79282981-79286980 bp, - strand Genetic Position: Chr2, 47.58 cM
• Alliance: Neurod1^tm1Jle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74715
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-neoR cassette replaced the second exon including the entire coding region. A beta-galactosidase fusion protein is expressed from this allele that reflects the endogenous gene expression pattern. (J:74715)

Expression

In Mice Carrying this Mutation:	2 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Neurod1 Mutation: 29 strains or lines available

References

• Original: J:74715 Miyata T, et al., NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus. Genes Dev. 1999 Jul 1;13(13):1647-52
• All: 22 reference(s)