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Targeted Allele Detail
Symbol: Il18tm1Khe
Name: interleukin 18; targeted mutation 1, Klaus Heeg
MGI ID: MGI:2385814
Synonyms: IL-18KO
Gene: Il18  Location: Chr9:50554827-50581840 bp, + strand  Genetic Position: Chr9, 27.75 cM
Germline Transmission:  Earliest citation of germline transmission: J:62263
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPart of exons 5 and 7 and all of exon 6 were replaced with a neomycin resistance cassette via homologous recombination. Gene expression was absent in livers of homozygous mutant animals as demonstrated by RNase protection assay. (J:62263)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il18 Mutation:  13 strains or lines available
Original:  J:62263 Hochholzer P, et al., Role of interleukin-18 (IL-18) during lethal shock: decreased lipopolysaccharide sensitivity but normal superantigen reaction in IL-18-deficient mice. Infect Immun. 2000 Jun;68(6):3502-8
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory