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Lamp2tm1Psa
Targeted Allele Detail
Nomenclature
Symbol: Lamp2tm1Psa
Name: lysosomal-associated membrane protein 2; targeted mutation 1, Paul Saftig
MGI ID: MGI:2385811
Synonyms: LAMP-2-, Lamp2tm1Psf
Gene: Lamp2  Location: ChrX:38401357-38456454 bp, - strand  Genetic Position: ChrX, 22.67 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64151
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe gene was disrupted by insertion of a neomycin resistance cassette into a coding exon via homologous recombination. Absence of RNA and protein expression in homozygous mutant animals was demonstrated by Northern and Western blot analysis of liver and kidney tissue. (J:64151)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lamp2 Mutation:  5 strains or lines available
References
Original:  J:64151 Tanaka Y, et al., Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice. Nature. 2000 Aug 24;406(6798):902-6
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/31/2018
MGI 6.12
The Jackson Laboratory