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Gtpbp1tm1Ynim
Targeted Allele Detail
Summary
Symbol: Gtpbp1tm1Ynim
Name: GTP binding protein 1; targeted mutation 1, Yasuharu Nishimura
MGI ID: MGI:2385801
Gene: Gtpbp1  Location: Chr15:79575046-79605680 bp, + strand  Genetic Position: Chr15, 37.85 cM, cytoband E3
Alliance: Gtpbp1tm1Ynim page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63937
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsTwo exons encoding the putative GTP-binding domain (amino acids 59-193) were replaced with a PGK-neo cassette via homologous recombination. Western blot analysis of brain lysates using antibodies directed against the N-terminal and C-terminal portions of the protein did not detect protein expression in homozygous mutant animals. (J:63937)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gtpbp1 Mutation:  33 strains or lines available
References
Original:  J:63937 Senju S, et al., Immunocytochemical analyses and targeted gene disruption of GTPBP1. Mol Cell Biol. 2000 Sep;20(17):6195-200
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory