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Targeted Allele Detail
Symbol: Itga2btm1Tlr
Name: integrin alpha 2b; targeted mutation 1, Diana Tronik-Le Roux
MGI ID: MGI:2385793
Synonyms: alphaIIb-
Gene: Itga2b  Location: Chr11:102453297-102470122 bp, - strand  Genetic Position: Chr11, 66.29 cM
Germline Transmission:  Earliest citation of germline transmission: J:63961
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by insertion of a TK-PGK-neo cassette into exon 1 via homologous recombination. Northern blot analysis showed the absence of Itga2b expression and presence of TK transcripts in the bone marrow of homozygous mutant animals. Immunoblot analysis using an antibody directed against human Itga2b confirmed absence of protein product in platelet extracts from homozygous mutant mice. (J:63961)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itga2b Mutation:  0 strains or lines available
Original:  J:63961 Tronik-Le Roux D, et al., Thrombasthenic mice generated by replacement of the integrin alpha(IIb) gene: demonstration that transcriptional activation of this megakaryocytic locus precedes lineage commitment. Blood. 2000 Aug 15;96(4):1399-408
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory