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Sos2tm1Esn
Targeted Allele Detail
Nomenclature
Symbol: Sos2tm1Esn
Name: SOS Ras/Rho guanine nucleotide exchange factor 2; targeted mutation 1, Eugenio Santos
MGI ID: MGI:2385790
Synonyms: sos2-/-
Gene: Sos2  Location: Chr12:69583762-69681852 bp, - strand  Genetic Position: Chr12, 28.93 cM, cytoband C3-D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63931
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of a highly conserved exon (encoding amino acids 855-893 in the central portion of the CDC25-H domain) with a PGK-neo cassette via homologous recombination. Western blot analysis of tissues from homozygous mutant animals using antibodies directed against the N-terminal and C-terminal regions of the protein did not detect any form of gene expression. (J:63931)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sos2 Mutation:  28 strains or lines available
References
Original:  J:63931 Esteban LM, et al., Ras-guanine nucleotide exchange factor sos2 is dispensable for mouse growth and development. Mol Cell Biol. 2000 Sep;20(17):6410-3
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory