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Ltb4r1tm1Adl
Targeted Allele Detail
Nomenclature
Symbol: Ltb4r1tm1Adl
Name: leukotriene B4 receptor 1; targeted mutation 1, Andrew D Luster
MGI ID: MGI:2385786
Synonyms: BLT1-, BLTR-
Gene: Ltb4r1  Location: Chr14:55765962-55768494 bp, + strand  Genetic Position: Chr14, 28.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63873
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe gene was disrupted by insertion of a neomycin resistance cassette into exon 2 just 3' of the translation initiation codon via homologous recombination. Northern blot analysis detected a mutant transcript containing the neomycin insert in neutrophils, macrophages, lymph nodes, lung, and spleen from homozygous mutant animals. (J:63873)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ltb4r1 Mutation:  13 strains or lines available
References
Original:  J:63873 Tager AM, et al., BLTR mediates leukotriene B(4)-induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis [see comments]. J Exp Med. 2000 Aug 7;192(3):439-46
All:  36 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/15/2020
MGI 6.15
The Jackson Laboratory