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Targeted Allele Detail
Symbol: Prkcdtm1Qxu
Name: protein kinase C, delta; targeted mutation 1, Qingbo Xu
MGI ID: MGI:2385756
Synonyms: PCKdelta-, PCKdelta KO
Gene: Prkcd  Location: Chr14:30595354-30626210 bp, - strand  Genetic Position: Chr14, 18.82 cM
Prkcdtm1Qxu/Prkcdtm1Qxu mice are protected from age-related hepatosteatosis

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:78680
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsThe translation initiation codon was disrupted by insertion of a lacZ-neo cassette into the first coding exon of the gene via homologous recombination. Protein product was absent in homozygous mutant animals as determined by Western blot analysis of heart, lung, and liver tissues. (J:78680)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 62 assay results
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prkcd Mutation:  11 strains or lines available
Original:  J:78680 Leitges M, et al., Exacerbated vein graft arteriosclerosis in protein kinase Cdelta-null mice. J Clin Invest. 2001 Nov;108(10):1505-12
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory