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Myd88tm1Aki
Targeted Allele Detail
Nomenclature
Symbol: Myd88tm1Aki
Name: myeloid differentiation primary response gene 88; targeted mutation 1, Shizuo Akira
MGI ID: MGI:2385681
Synonyms: MyD88-, MyD88 KO
Gene: Myd88  Location: Chr9:119335934-119341411 bp, - strand  Genetic Position: Chr9, 71.33 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:48832
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a 1.0 kb genomic fragment that contained sequences encoding the C-terminal cytoplasmic domain of the protein. Northern blot analysis confirmed that the encoded mRNA could not be detected in the liver and spleen of homozygous mice. (J:48832, J:91950)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Myd88 Mutation:  18 strains or lines available
References
Original:  J:48832 Adachi O, et al., Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity. 1998 Jul;9(1):143-50
All:  1070 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory