Myd88^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Myd88^tm1Aki
• Name: myeloid differentiation primary response gene 88; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:2385681
• Synonyms: MyD88-, MyD88 KO
• Gene: Myd88 Location: Chr9:119165000-119169084 bp, - strand Genetic Position: Chr9, 71.33 cM
• Alliance: Myd88^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48832
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a 1.0 kb genomic fragment that contained sequences encoding the C-terminal cytoplasmic domain of the protein. Northern blot analysis confirmed that the encoded mRNA could not be detected in the liver and spleen of homozygous mice. (J:48832, J:91950)

Disease models

Expression

In Mice Carrying this Mutation:	1 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 9 strains available Cell Lines: 0 lines available
• Carrying any Myd88 Mutation: 50 strains or lines available

References

• Original: J:48832 Adachi O, et al., Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity. 1998 Jul;9(1):143-50
• All: 1392 reference(s)