Fen1^tm1Rak
Targeted Allele Detail

Summary

• Symbol: Fen1^tm1Rak
• Name: flap structure specific endonuclease 1; targeted mutation 1, Raju Kucherlapati
• MGI ID: MGI:2385597
• Synonyms: Fen1^null
• Gene: Fen1 Location: Chr19:10176496-10181533 bp, - strand Genetic Position: Chr19, 6.54 cM
• Alliance: Fen1^tm1Rak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77962
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced with a neomycin selection cassette and incorporated into the endogenous locus via homologous recombination. (J:77962)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Fen1^tm1Rak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fen1 Mutation: 30 strains or lines available

References

• Original: J:77962 Kucherlapati M, et al., Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9924-9
• All: 2 reference(s)