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Tg(Tuba1-MAPT)14Vle
Transgene Detail
Nomenclature
Symbol: Tg(Tuba1-MAPT)14Vle
Name: transgene insertion 14, Virginia M Y Lee
MGI ID: MGI:2385585
Synonyms: Talpha1-3RT
Transgene: Tg(Tuba1-MAPT)14Vle  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F1
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Tuba1-MAPT)14Vle expresses 1 gene
 
Mutation detailsA murine Tuba1 promoter was adjoined to a minigene comprised of the complete coding region of the MAPT gene that included modified intronic sequence flanking exons 2 and 3 to drive expression of the downstream gene construct in the CNS. Western blot analysis showed the MAPT protein to be expressed at levels approximately 5.5 fold higher than the endogenous mouse counterpart. (J:78400)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:78400 Higuchi M, et al., Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration. Neuron. 2002 Aug 1;35(3):433-46
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory