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Pla2g4atm1Tksh
Targeted Allele Detail
Nomenclature
Symbol: Pla2g4atm1Tksh
Name: phospholipase A2, group IVA (cytosolic, calcium-dependent); targeted mutation 1, Takao Shimizu
MGI ID: MGI:2385582
Synonyms: cpla2-, cPLA2alpha, cPLA2 GIVA, IVA PLA2-
Gene: Pla2g4a  Location: Chr1:149829618-149961290 bp, - strand  Genetic Position: Chr1, 63.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:39254
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of part of the exon encoding the lipase consensus motif and serine 228, a residue required for enzymatic activity. Absence of gene expression in the spleen of homozygous animals was verified by Northern blot and Western blot analyses. (J:39254)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pla2g4a Mutation:  26 strains or lines available
References
Original:  J:39254 Uozumi N, et al., Role of cytosolic phospholipase A2 in allergic response and parturition. Nature. 1997 Dec 11;390(6660):618-22
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory