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Hif1atm1Rsjo
Targeted Allele Detail
Nomenclature
Symbol: Hif1atm1Rsjo
Name: hypoxia inducible factor 1, alpha subunit; targeted mutation 1, Randall S Johnson
MGI ID: MGI:2385358
Synonyms: Hif1alpha-, HIF-1alpha-
Gene: Hif1a  Location: Chr12:73901375-73947530 bp, + strand  Genetic Position: Chr12, 31.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:48084
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence in exon 2 encoding the basic helix-loop-helix domain was replaced with a neomycin selection cassette. The absence of transcript and functional protein was shown by Northern blot analysis and an electromobility shift assay. (J:48084)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hif1a Mutation:  11 strains or lines available
References
Original:  J:48084 Ryan HE, et al., HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J. 1998 Jun 1;17(11):3005-15
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/07/2020
MGI 6.15
The Jackson Laboratory